논문검색
Author Young Woong Won, Young Hyo Lim, Ho Yong Park, Ho Suk Oh, Jung Hye Choi, Young Yeul Lee, In Soon Kim, Il Young Choi, Myung Ju Ahn
Place of duty Department of Internal Medicine, College of Medicine, Hanyang University, Seoul, Korea.
Title Phase II Study of Irinotecan, 5-Fluorouracil, and Leucovorin in Relapsed or Metastatic Colorectal Cancer as First-line Therapy
Publicationinfo Cancer Research and Treatment 2004 Aug; 036(04): 235-239.
Key_word Irinotecan,5-Fluorouracil,Leucovorin,Metastatic colorectal cancer
Full-Text
Abstract Background: The purpose of this study was to assess the efficacy and toxicity of biweekly irinotecan plus 5-fluorouracil (FU) and leucovorin (LV) in patients with relapsed or metastatic colorectal cancer. Materials and Methods: Between March 2002 and May 2004, 24 patients with histologically confirmed relapsed or metastatic colorectal cancer were enrolled in this study. One chemotherapy cycle consisted of irinotecan 180 mg/m2 on days 1 and 15; 5-FU 400 mg/m2 bolus IV with 600 mg/m2 by a 22 hour intravenous infusion on days 1, 2, 15 and 16; and leucovorin 20 mg/m2 on days 1, 2, 15 and 16, every 4 weeks. Results: The median age of the 24 was 57.5 years (range, 38~69). Their metastatic sites included: the liver (62.5&), lung (20.8&), peritoneum (16.7&), lymph node (12.5&), ovary (8.3&) and pelvis/vagina (8.3&). Twenty- two patients were evaluable for a response. Six and 7 patients achieved partial responses and stable diseases, respectively. The overall response rate was 27.3& (95& Confidence interval; 10.3~44.5&). The median follow-up duration for surviving patients was 14.7 months (range, 1.7~26.5). Median overall survival (OS) and 1-year OS rates were 19 months and 86.3&, respectively. Median response duration and median progression free survival were 7.47 and 5.57 months, respectively. A total of 83 cycles (median 4 cycles) were administered. The main non-hematologic toxicities were nausea/vomiting (44.5&/ 18.1&) and diarrhea (8.4&). The most common hematologic toxicity was NCI grade I/II anemia (31.3&) and grade I/II neutropenia was 10.8&. There was no life-threatening toxicity. Conclusion: The results suggested that irinotecan, 5-FU and leucovorin combination chemotherapy in a biweekly schedule is a practical and tolerable treatment option in patients with advanced colorectal cancer. (Cancer Research and Treatment 2004;36:235-239)